Charles Vaske, Ph.D.
Chief Scientific Officer
Charlie has been working in genomics and systems biology for a decade. As an undergraduate at Washington University in St. Louis, Charlie worked on probabilistic models to find genes from raw DNA sequence. In 2003, he graduated with a B.S. in Computer Science with a major in Mathematics. He then entered the UC Santa Cruz bioinformatics program under a NSF Graduate Research Fellowship, earning his Ph.D under the advisement of Prof. Joshua Stuart. He developed probabilistic methods for discovering gene interactions in signaling pathways, including a signaling network describing the invasion mechanism of colon cancer.
Prior to co-founding Five3 Genomics, Charlie held post-doctoral positions with Prof. Olga Troyanskaya, of Princeton University, and Prof. David Haussler of University of California, Santa Cruz. Drawing from his prior probabilistic modeling and cancer research experience, he developed the PARADIGM pathway inference method with Steve Benz to tackle the problem of integrating multiple genomic types in cancer.