Five3 Genomics

About Us

World-class researchers and clinicians advising the next generation of personalized care.

Margret Tempero

Margaret Tempero


Dr. Tempero is Deputy Director and Director of Research Programs and leads the Pancreas Cancer Program at the UCSF Helen Diller Family Comprehensive Cancer Center (HDFCCC). Her research career has focused on pancreatic ductal adenocarcinoma especially in the area of investigational therapeutics. She was a pioneer in the use of antibody-based therapies and helped develop the fixed dose rate concept for gemcitabine. Her group has developed effective gemcitabine combinations and provided a foundation for using CA19-9 as a surrogate for survival in clinical trials. Currently her group is assessing molecular subtypes and molecular enrichment for selecting new drugs for clinical evaluation.

Dr. Tempero directed the first GI SPORE devoted to pancreatic cancer when she was on the faculty of the University of Nebraska and subsequently led the NCI funded U54 Molecular Target Assessment Team at UCSF. She organized the first Pancreas Cancer Think Tank in 1999 and co-led the NCI sponsored Progress Review Group on Pancreatic Cancer in 2000. She has served as the Chair of the NCCN Guidelines Panel on Pancreatic Cancer since 2000. She also serves on the Pancreatic Cancer Task Force for the NCI intergroup and recently co-organized the State of the Science meeting on pancreatic cancer at the NCI.

Dr. Tempero has extensive experience in scientific review and administration, training and oversight. She co-directed the AACR/ASCO Methods in Clinical Cancer Research in Vail for 3 years and spent 9 years of service teaching at this course and in similar courses in Europe and Australia. She was founding Chair of the NCI Clinical Oncology Study Section (CONC) and served as a member and Chair (2-year term) of the NCI Board of Scientific Counselors Subcommittee A. She is on the External Advisory Boards of the Pancreas SPORE at MDACC and the GI SPOREs at the University of Arizona and Northwestern (application in progress). She is, or has been, on the Scientific Advisory Boards of the Lustgarten Foundation, the Pancreatic Cancer Action Network, the V Foundation, The Alberta Canada Cancer Board and a member of the Oncology Drug Advisory Committee for the FDA and the EORTC. She has held many appointments at AACR and ASCO and has served as a member of the ASCO Board of Directors and as ASCO President in 2004. She served as Deputy Director and Interim Director for the UNMC Eppley Cancer Center until 1999 and is Chief Emeritus of the Division of Medical Oncology at UCSF (2000 - 2007).

The Team

Our team comes from a wide variety of backgrounds, but all have a common purpose.

  • Stephen Benz
    Steve Benz, Ph.D.
  • Zachary Sandborn
    J. Zachary Sanborn
  • Charles Vaske
    Charles Vaske, Ph.D.
  • Jim Kytola
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